Tuberculosis (TB) Testing

QuantiFERON®-TB Gold Plus (QFT®-Plus): The Modern Alternative to Tuberculin Skin Tests (TST)

Introduction to QuantiFERON-TB Gold Plus (QFT-Plus)
QuantiFERON®-TB Gold Plus (QFT®-Plus) represents the fourth generation of QuantiFERON-TB testing technology. This advanced testing method is recommended by the Centers for Disease Control and Prevention (CDC) for specific cases where the traditional tuberculin skin test (TST) may be used.1 Interferon Gamma Release Assays (IGRAs), like QFT-Plus, offer a modern, improved alternative to the TST, which has been in use for over 100 years.

Advantages of QFT-Plus over TST

  • Accuracy: QFT-Plus is proven to be more accurate than TST in detecting latent tuberculosis (TB) infections.3
  • Reliability: It has shown greater reliability in identifying individuals who may progress to active TB.4
  • Specificity: With a specificity of over 97%,1 QFT-Plus almost eliminates false positives. In contrast, TST false-positive rates can range from as low as 3% in non-BCG-vaccinated populations5 to as high as 65% in BCG-vaccinated individuals when a 10-mm induration is used as a cutoff.6
  • Sensitivity: The sensitivity of QFT-Plus exceeds 94%,1 greatly reducing false-negative results.

Advanced CD8 Cell Technology
QuantiFERON-TB Gold Plus (QFT-Plus) introduces cutting-edge CD8 cell technology. CD4 T cells are critical in immunological control through the secretion of cytokine IFN-y. However, recent research highlights the role of CD8+ T cells in producing IFN-y and aiding host defense against M. tuberculosis.

Key Benefits of QFT-Plus Compared to TST

  • Single Visit Convenience: TST requires multiple visits for administration and results reading, whereas QFT-Plus only requires one office visit for a blood draw.
  • Minimized False Positives: QFT-Plus is more specific, nearly eliminating false positives compared to TST.
  • Reduced False Negatives: It is more sensitive than TST, resulting in fewer false negatives.
  • Objective Results: QFT-Plus delivers clear, objective results compared to the subjective nature of TST.
  • No Interference from BCG Vaccinations: Unlike TST, QFT-Plus is not affected by prior BCG vaccinations.
  • No Boosting Effect: QFT-Plus does not boost subsequent test results and is less influenced by prior TST tests.

Why Choose Lab Test Solutions for QuantiFERON-TB Gold Plus Testing?

At Lab Test Solutions, we understand the importance of accurate and timely TB testing. That’s why we offer the QuantiFERON-TB Gold Plus test through our extensive network of certified labs, ensuring you receive the highest quality service with fast, reliable results.

  • Convenient Testing Locations: With over 3,000 testing centers nationwide, finding a location close to your home or workplace is easy and convenient.
  • Certified Laboratories: We work exclusively with SAMHSA-certified labs to ensure every test meets the highest industry standards for accuracy and compliance.
  • Exceptional Support: Our knowledgeable team is here to guide you through the process, from registration to receiving your results. We prioritize confidentiality and accuracy in all our services.

Choose Lab Test Solutions for your QuantiFERON-TB Gold Plus test and experience a more convenient, reliable, and efficient approach to TB testing. Contact us today to schedule your test or learn more about our comprehensive testing services.

  • Results are not subject to reader bias
  • Accuracy is not affected by prior BCG vaccination
  • Requires only 1 patient visit (2-4 required for TST)
  • Reduced staff time and avoidance of unnecessary follow-up, additional treatment, and treatment due to false-positive TST results2